α- 硝基酮类的合成

张寒青 , 潘馨慧 , 张珂 , 王航宇 , 王金辉 ,

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石河子大学学报 ›› 2017, Vol. 35 ›› Issue (5) : 602-605. DOI: 10.13880/j.cnki.65- 1174/n.2017.05.013
医学·药学

α- 硝基酮类的合成

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Synthesis of α-nitroKetone

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摘要

为找到一种简便易行的方法对 α- 硝基酮类化合物进行合成。采用取代的苯甲酰氯和硝基甲烷为原料,经过 两步反应来获得有机反应中重要的中间体 α- 硝基酮。结果显示,通过该方法合成了 12 种取代的硝基苯乙酮,其 产率在 68%-95%之间,结构通过 1 H NMR 验证正确。由此可知,使用取代的苯甲酰氯和硝基甲烷为原料,可以获得 相应的硝基酮,并有较为满意的产率。

Abstract

To find a simple and convenient method for the α-nitroKetone synthesis. The substituted benzoyl chloride and nitromethane were used as raw materials in the study; the two step reaction was used to obtain the important intermediate. The results showed that 12 kinds of substituted acetophenone were synthesized by this method, the yield was 68% -95%, and the structure was verified by 1 H NMR. The conclusion is that by using substituted benzoyl chloride and nitromethane as raw materials, the corresponding nitro group can be obtained, and the yield is satisfactory.

关键词

α- 硝基酮 / 合成 / 酰氯 / 硝基甲烷

Key words

α-nitro ketone / synthesis / chloride / nitromethane

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张寒青 , 潘馨慧 , 张珂 , 王航宇 , 王金辉 , . α- 硝基酮类的合成. 石河子大学学报. 2017, 35(5): 602-605 https://doi.org/10.13880/j.cnki.65- 1174/n.2017.05.013
Zhang Hanqing , Pan Xinghui , Zhang Ke , Wang Hangyu , Wang Jinhui, . Synthesis of α-nitroKetone. Journal of Shihezi University. 2017, 35(5): 602-605 https://doi.org/10.13880/j.cnki.65- 1174/n.2017.05.013

参考文献

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新疆特种植物药资源教育部重点实验室开放课题(20150203)
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